Last data update: May 06, 2024. (Total: 46732 publications since 2009)
Records 1-5 (of 5 Records) |
Query Trace: Vanover C[original query] |
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Rebuilding Caribbean environmental health post-crisis programs: A preliminary study for virtual mentorship
DeVito Roseann , David Dyjack Elizabeth Landeen , Labbo Rebecca , Gill Gagandeep , Gerding Justin , Kalis Martin A , Daly Scott , Lopez Raymond , Somaiya Chintan , Chera Sukhdeep , Vanover Christine , Fahnestock Lindsay , Randhawa Manjit . J Environ Health 2024 86 (6) 8-13 After the hurricanes in 2017 in the U.S. Caribbean, it was essential to rebuild, strengthen, and sustain essential environmental health (EH) services and systems. The National Environmental Health Association, in partnership with the Centers for Disease Control and Prevention, developed an online mentorship program for newly hired and existing EH staff and health department leadership in Caribbean health departments. Participants were provided with both practical and didactic learning and were allowed to evaluate the program. Both mentors and mentees were highly satisfied with the knowledge and skills acquired, and mentees expressed it was relevant to their daily work. Based on the findings, we recommend both an online and a hybrid mentorship program for leadership- and inspector-level workforces in EH and potentially in other fields. |
A review of zoonotic disease threats to pet owners: A compendium of measures to prevent zoonotic diseases associated with non-traditional pets: Rodents and other small mammals, reptiles, amphibians, backyard poultry, and other selected animals
Varela K , Brown JA , Lipton B , Dunn J , Stanek D , Behravesh CB , Chapman H , Conger TH , Vanover T , Edling T , Holzbauer S , Lennox AM , Lindquist S , Loerzel S , Mehlenbacher S , Mitchell M , Murphy M , Olsen CW , Yager CM . Vector Borne Zoonotic Dis 2022 22 (6) 303-360 As ownership of NTP species is increasing, the number and size of outbreaks associated with NTPs in recent years has also increased. Non-traditional pet owners and members of the public who may come into contact with NTPs should be aware of the potential health risks and understand that even apparently healthy animals can transmit pathogens. The recommendations in this Compendium provide public health professionals, animal health professionals, industry, and healthcare providers (including veterinarians, physicians, and allied health professionals) resources to prevent disease transmission and spread. These recommendations aim to benefit all partners by preventing human infections,maintaining animal health and welfare, and providing economic benefits. © 2022 Mary Ann Liebert Inc.. All rights reserved. |
Tick talk: Keeping environmental health up with current trends
Vanover C , Ruiz A . J Environ Health 2019 81 (7) 36-38 Tickborne diseases are on the rise in the U.S. Recent studies show that the number of reported cases of tickborne disease doubled from 22,527 cases in 2004 to 48,610 cases in 2016. Current tickborne disease control strategies heavily rely on personal protective behaviors at the individual and household level, which poses a challenge for environmental health professionals who are often called upon to address tickborne disease concerns in their communities. Approximately half of all state and local health departments provide vector control services that are commonly under the purview of environmental health programs. While vector control might be a priority for many health departments, there is a need to strengthen and build vector control capacity. | | This month's column highlights two federal initiatives that could enhance vector control services in the U.S.: the Tick-Borne Disease Working Group and the establishment of Regional Centers of Excellence in Vector-Borne Diseases. Furthermore, the 10 Essential Environmental Public Health Services can provide a framework that can be used to encourage a comprehensive and programmatic approach to providing tick control services and building capacity. Finally, the column provides information about several Centers for Disease Control and Prevention resources and tools that environmental health professionals can leverage to enhance their knowledge of vectors and control strategies, as well as strengthen their vector control programs. |
A web-based review of environmental health vector control services in the United States
Ruiz A , Vanover C , Parale A , Gerding J . J Environ Health 2018 80 (8) 36-38 The authors provide insights and information about environmental health programs, trends, issues, and resources. Topics discussed include the need and significance for mosquito control in local jurisdictions, the role of environmental health professionals in influencing the scope of vector control services in the U.S., and environmental health vector control opportunities. |
Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission
Snyder GL , Vanover KE , Zhu H , Miller DB , O'Callaghan JP , Tomesch J , Li P , Zhang Q , Krishnan V , Hendrick JP , Nestler EJ , Davis RE , Wennogle LP , Mates S . Psychopharmacology (Berl) 2014 232 (3) 605-21 RATIONALE: Schizophrenia remains among the most prevalent neuropsychiatric disorders, and current treatment options are accompanied by unwanted side effects. New treatments that better address core features of the disease with minimal side effects are needed. OBJECTIVES: As a new therapeutic approach, 1-(4-fluoro-phenyl)-4-((6bR, 10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de] quinoxalin-8-yl)-butan-1-one (ITI-007) is currently in human clinical trials for the treatment of schizophrenia. Here, we characterize the preclinical functional activity of ITI-007. RESULTS: ITI-007 is a potent 5-HT2A receptor ligand (K i = 0.5 nM) with strong affinity for dopamine (DA) D2 receptors (K i = 32 nM) and the serotonin transporter (SERT) (K i = 62 nM) but negligible binding to receptors (e.g., H1 histaminergic, 5-HT2C, and muscarinic) associated with cognitive and metabolic side effects of antipsychotic drugs. In vivo it is a 5-HT2A antagonist, blocking (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI)-induced headtwitch in mice with an inhibitory dose 50 (ID50) = 0.09 mg/kg, per oral (p.o.), and has dual properties at D2 receptors, acting as a postsynaptic D2 receptor antagonist to block D-amphetamine hydrochloride (D-AMPH) hyperlocomotion (ID50 = 0.95 mg/kg, p.o.), yet acting as a partial agonist at presynaptic striatal D2 receptors in assays measuring striatal DA neurotransmission. Further, in microdialysis studies, this compound significantly and preferentially enhances mesocortical DA release. At doses relevant for antipsychotic activity in rodents, ITI-007 has no demonstrable cataleptogenic activity. ITI-007 indirectly modulates glutamatergic neurotransmission by increasing phosphorylation of GluN2B-type N-methyl-D-aspartate (NMDA) receptors and preferentially increases phosphorylation of glycogen synthase kinase 3beta (GSK-3beta) in mesolimbic/mesocortical dopamine systems. CONCLUSION: The combination of in vitro and in vivo activities of this compound support its development for the treatment of schizophrenia and other psychiatric and neurologic disorders. |
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